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KMID : 0360319920240050737
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Journal of Korean Cancer Research Association
1992 Volume.24 No. 5 p.737 ~ p.742
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5-Fluorouracil and Low dose Leucovorin in Advanced Colorectal Carcinoma
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윤성수
임영혁/장정순/이재용/서창인/허대석/방영주/김노경
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Abstract
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We studied the therapeutic effect of 5-fluoruracil in combination with low dose leucovorin in patients with recurrent or metastatic carcinoma of the colon or rectum. 40 patients with clearly measurable lesions were entered into this study between
Sep.
1989 to May 1991 and two were excluded from the analysis because one patient did not meet the eligibility criteria and the other was lost to follow-up. They were treated with leucovorin, 20mg/m*/day iv bolus, followed by 5-fluorouracil
370mg/m*/day
iv
bolus for 5 consecutive days. This regimen was repeated every 4 weeks and 5-fluourouracil doses were escalated to 420mg/m*/day if the previous dose was tolerable. Male to female ratio was 25 to 13 with median age of 54 years(32~81 years).22
patients had
previous history of chemotherapy and 16 were previously untreated.
There was no complete and the partial response rate was 26.4%(10 of 38 patients).
The median response duration was 5 months and the median tme to progression was 3 months. Hematologic toxicities were mild and the rates of grade 3 or greater nonhematologic toxicity were 7.8%(3 of 38 patients). There was no treatment-related
fatality.
Our results indicate that the combination of 5-fluorouracil and leucovorin has modest activity for patients with metastatic or recurrent carcinoma of the rectum and colon.
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KEYWORD
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